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The Royal Caribbean Oasis of the Seas is scheduled for her maiden voyage on
December 12, 2009. The ship will sail from her home port of Fort Lauderdale, Florida embarking on 7-Night Caribbean Cruises.
From December 2009 through April 2010, the Oasis will sail to the Eastern Caribbean.
Beginning in May 2010, the Oasis of the Seas will alternate between Eastern and Western Caribbean cruises. The Western Caribbean cruise itinerary will include the ports of Labadee (Royal Caribbean's Private Island), Falmouth, Jamaica (NEW PORT), and Cozumel, Mexico. Below is the detailed schedule for the Western Caribbean itinerary:
| Day | Port | Arrive | Depart |
| Sat. | Fort Lauderdale, Florida | 5:00 pm | |
| Sun. | Cruising (At Sea) | ||
| Mon. | Labadee (Private Island) | 8:00 am | 5:00 pm |
| Tue. | Falmouth, Jamaica | 10:00 am | 6:00 pm |
| Wed. | Cruising (At Sea) | ||
| Thu. | Cozumel, Mexico | 8:00 am | 8:00 pm |
| Fri. | Cruising (At Sea) | ||
| Sat, | Fort Lauderdale, Florida | 7:00 am |